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The October 30, 2006 edition of the Wall Street Journal reported that preliminary studies on the red wine compound resveratrol may extend animal life spans by as much as 40%! Resveratrol was also mentioned for its potential life-extending properties in an article about restricted-calorie diets in the October 31, 2006 edition of The New York Times. The scientific journal Nature published the original research that both the Wall Street Journal and the New York Times reference.
The study conducted on mice by Harvard Medical School and the National Institute of Aging researchers, finds that resveratrol negates the negative effects of a high-fat, high-calorie diet, a finding which experts are calling remarkable. In the study, one-year-old mice were split into three groups, a control group of mice fed a normal diet, a group fed a high-fat (60% fat), high calorie diet, and a group fed the same high-fat, high-calorie diet plus resveratrol. Within six months both groups of mice on the special diet had grown fat. However after a year, the mice which were also receiving the resveratrol seemed healthier. They did not develop the insulin resistance (a diabetes-like disease), heart disease or liver damage that their counterparts did. In addition, the group getting the resveratrol had a 31% lower risk of death.
Overweight aged male mice whose high calorie (fat) diet was supplemented by resveratrol, a natural compound found in common foods like grapes, wines and nuts, had better health and survival than aged overweight mice who did not receive it, according to a study published online in the Nov. 1 issue of Nature. The study was conducted and supported in part by the National Institute on Aging (NIA) of the National Institutes of Health (NIH).
The findings are the first to demonstrate that resveratrol, an activator of a family of enzymes called sirtuins, could affect the health and survival of mammals. The findings build upon previous research on resveratrol, a small molecule produced by certain plants in response to stress. Studies over the last few years have found that resveratrol can extend lifespan in yeast, worms, flies and fish.
The study was a collaborative effort between the laboratories of Rafael de Cabo, Ph.D., at the NIA, David A. Sinclair, Ph.D., at Harvard Medical School and an international group of researchers. In an earlier article, Resveratrol Extends Lifespan by 50%.
“There is currently intense interest in identifying interventions that can be applied to improve health and survival, especially as our society ages. Today’s basic science findings are a notable step in this effort,” notes Richard J. Hodes, M.D., director of the NIA. “At the same time, it should be cautioned that this is a study of male mice, and we still have much to learn about resveratrol’s safety and effectiveness in humans.”
The report describes the result of studies of year-old (middle-aged) mice placed on three different diets for six months: a standard mouse diet, a high calorie (fat) diet and a high calorie (fat) diet supplemented with resveratrol. After six months, the scientists observed a clear trend toward increased survival and insulin sensitivity (important for the body’s efficient processing of glucose into energy) in the high calorie diet supplemented with resveratrol relative to that seen on the high fat diet without resveratrol supplementation. In the study, resveratrol shifted the physiology of middle-aged mice on a high calorie diet towards that of mice on a standard diet and increased their survival.
The scientists reported that:
“After six months, resveratrol essentially prevented most of the negative effects of the high calorie diet,” de Cabo concludes. “There is a lot of work ahead that will help us better understand resveratrol’s roles and the best applications for it.”
De Cabo and Sinclair did not observe toxic effects of resveratrol on the mice at the doses studied. However, de Cabo emphasized, the safety and effectiveness of the substance for humans to address aging and age- or obesity-related conditions is far from demonstrated. Some contraindications are already known, including evidence from earlier animal studies that have shown high doses of resveratrol to affect blood platelets, which could increase the risk of bleeding when taken with anticoagulant, anti-platelet or nonsteroidal anti-inflammatory drugs.
Baur, J., Pearson, K et al. Resveratrol improves health and increases survival of mice on a high-calorie diet Nature 2006. DOI 10.1038/nature05354
As reported by the U.S. National Institutes of Health (NIH), National Institute of Aging, November 1, 2006.