Evaluation of the effects of Neptune Krill Oil on the Clinical Course of Hyperlipidemia

JSS medical research inc. June 7, 2003

Abstract

Neptune Krill Oil was tested on a group 120 patients with mild to high hyperlipidemia (high cholesterol). In a multi-clinical, 3-month, prospective, randomized study, the patients were randomly assigned to 4 groups: Neptune Krill Oil 2-3 gm/day (based on BMI), 1.5-1.0 gm/day (based on BMI), an active control group taking 3.0 gm/day fish oil, and a placebo group.

Primary parameters tested were: total cholesterol, triglycerides, HDL and LDL cholesterol, and Cholesterol/HDL ratio.

The results of the present study demonstrate within high levels of confidence that:

1. NKO^™ is effective for the management of hyperlipidemia by significantly reducing total cholesterol, LDL and triglycerides and increasing HDL levels.

2. NKO^™ 1.5 gr/day is more effective than Fish Oil 3.0 gr/day for the management of hyperlipidemia by significantly reducing LDL levels.

3. At equal doses, NKO^™ 3.0 gr/day is more effective than Fish Oil 3.0 gr/day for the management of hyperlipidemia by significantly reducing triglycerides and LDL levels.

STATISTICAL RATIONALE AND ANALYSIS:

A sample size of 120 patients (30 patients/group) will provide 90% power to detect a 15% change in total cholesterol from baseline to 3 months.

Within group differences reflecting changes over time for the same patient were assessed for statistical significance with the Paired Student’s t-test. Between group differences were assessed with planned comparisons of one way analysis of variance.

MAIN STUDY GROUP ANALYSIS

BMI DEPENDENT NKO™™ SUBGROUP ANALYSIS

GROUP C1 : 2 g NKO – Subgroup of C (15 patients)
	0 days	90 days	% Change
	mmol/l
Total Cholesterol	6.40	5.24	-18.13%
LDL	4.73	2.96	-37.42%
HDL	1.32	2.05	55.30%
Triglycerides	1.81	1.31	-27.62%

GROUP D1 :– Subgroup of D (17 patients) -
1.0 g NKO (0		– 90 days)		0.5 g NKO (91 – 180 days)
	0 days	90 days	% Change	91 - 180 days	% Change
	mmol/l			mmol/l
Total Cholesterol	6.10 5.28		-13.44%	4.92	-19.34%
LDL	4.34 2.95		-32.03%	2.93	-32.49%
HDL	1.48 2.13		43.92%	1.96	32.43%
Triglycerides	1.36 1.21		-11.03%	1.6	17.65%
GROUP D2 :– Subgroup of D (13 patients) -
1.5 g NKO (0		– 90 days)		0.5 g NKO (91 – 180 days)
	0 days	90 days	% Change	90 - 180 days	% Change
		mmol/l		mmol/l
Total Cholesterol	5.98	5.16	-13.71%	4.88	-18.39%
LDL	4.26	2.74	-35.70%	2.85	-33.10%
HDL	1.52	2.17	42.76%	2.01	32.24%
Triglycerides	1.43	1.26	-11.89%	1	-30.07%

4. NKO^™ 1.0 - 1.5 gr/day (BMI dependent) is significantly more effective than Fish Oil 3.0 gr/day for the reduction of:

a. Glucose

b. Low Density Lipoprotein (LDL)

5. NKO^™ 2.0 - 3.0 gr/day (BMI dependent) is significantly more effective than Fish Oil 3.0 gr/day for the reduction of:

a. Glucose

b. Triglycerides

c. Low Density Lipoprotein (LDL)

6. NKO^™ at a maintenance dose of 0.5 gr/day is significantly effective for maintenance within normal ranges of:

a. Glucose

b. Total cholesterol

c. Triglycerides

d. Low Density Lipoprotein (LDL)

e. Cholesterol : HDL ratio

f. High Density Lipoprotein (HDL)

Recommended Dosage:

According to the results of the present study, the recommended dose of Neptune Krill Oil for the management of blood lipids and glucose within normal levels is 1.0­1.5g/day (BMI dependent) for 30 days (booster dose) and continuing with a maintenance dose of 0.5g/day.

Conclusion

The results of the present study demonstrate within high levels of confidence that:

1. NKO^™ is effective for the management of hyperlipidemia by significantly reducing total cholesterol, LDL and triglycerides and increasing HDL levels.

2. NKO^™ 1.5 gr/day is more effective than Fish Oil 3.0 gr/day for the management of hyperlipidemia by significantly reducing LDL levels.

3. At equal doses, NKO^™ 3.0 gr/day is more effective than Fish Oil 3.0 gr/day for the management of hyperlipidemia by significantly reducing triglycerides and LDL levels.

Source:

Evaluation of the effects of Neptune krill oil on the clinical course of hyperlipidemia
Alternative Medicine Review, Dec, 2004 by Ruxandra Bunea, Khassan El Farrah, Luisa Deutsch

Read the entire study at http://findarticles.com/p/articles/mi_m0FDN/is_4_9/ai_n9485702

Key concepts: Neptune Krill Oil, EPA, DHA, blood lipid lowering, cholesterol, triglycerides, LDL, HDL